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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOP2B All Species: 32.12
Human Site: Y291 Identified Species: 50.48
UniProt: Q02880 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q02880 NP_001059.2 1626 183267 Y291 P V N G F R S Y V D L Y V K D
Chimpanzee Pan troglodytes XP_516332 1634 184611 Y299 P V N G F R S Y V D L Y V K D
Rhesus Macaque Macaca mulatta XP_001092092 1620 182490 Y285 P V N G F R S Y V D L Y V K D
Dog Lupus familis XP_534241 2041 231068 Y709 P V N G F R S Y V D L Y V K D
Cat Felis silvestris
Mouse Mus musculus Q64511 1612 181890 Y279 P V N G F R S Y V D L Y V K D
Rat Rattus norvegicus P41516 1526 173202 L273 R S Y V D M Y L K D K V D E T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507216 1923 216719 Y594 P V N G F R S Y V D L Y V K D
Chicken Gallus gallus O42131 1627 183228 Y296 P V N G F R S Y V D L Y V K D
Frog Xenopus laevis NP_001082502 1579 178601 L273 R T Y V E M Y L K D K L D E T
Zebra Danio Brachydanio rerio NP_001038656 1618 182448 Y290 P V N S F R S Y V D F Y V K D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P15348 1447 164377 V227 M S R R A Y D V A A S S K G V
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q23670 1520 172316 K300 N G K R I P I K G F E D Y V Q
Sea Urchin Strong. purpuratus XP_783546 1448 163750 S228 N N M S K T T S P K I T P F E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P30182 1473 164089 K253 D I A G C L G K S V K V E L N
Baker's Yeast Sacchar. cerevisiae P06786 1428 164196 M208 P D L T R F G M K E L D N D I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.3 98.5 78.1 N.A. 95.6 66.2 N.A. 79.3 89.2 66.6 73.6 N.A. 50.3 N.A. 49.5 57.3
Protein Similarity: 100 98.5 99.1 78.8 N.A. 97.2 78.1 N.A. 81.8 93.8 78.7 83.8 N.A. 64.3 N.A. 65.8 69.9
P-Site Identity: 100 100 100 100 N.A. 100 6.6 N.A. 100 100 6.6 86.6 N.A. 0 N.A. 0 0
P-Site Similarity: 100 100 100 100 N.A. 100 13.3 N.A. 100 100 13.3 86.6 N.A. 0 N.A. 0 20
Percent
Protein Identity: N.A. N.A. N.A. 43.3 40.7 N.A.
Protein Similarity: N.A. N.A. N.A. 59 56.8 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 0 7 0 0 0 7 7 0 0 0 0 0 % A
% Cys: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 7 0 0 7 0 7 0 0 67 0 14 14 7 54 % D
% Glu: 0 0 0 0 7 0 0 0 0 7 7 0 7 14 7 % E
% Phe: 0 0 0 0 54 7 0 0 0 7 7 0 0 7 0 % F
% Gly: 0 7 0 54 0 0 14 0 7 0 0 0 0 7 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 7 0 0 7 0 7 0 0 0 7 0 0 0 7 % I
% Lys: 0 0 7 0 7 0 0 14 20 7 20 0 7 54 0 % K
% Leu: 0 0 7 0 0 7 0 14 0 0 54 7 0 7 0 % L
% Met: 7 0 7 0 0 14 0 7 0 0 0 0 0 0 0 % M
% Asn: 14 7 54 0 0 0 0 0 0 0 0 0 7 0 7 % N
% Pro: 60 0 0 0 0 7 0 0 7 0 0 0 7 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % Q
% Arg: 14 0 7 14 7 54 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 14 0 14 0 0 54 7 7 0 7 7 0 0 0 % S
% Thr: 0 7 0 7 0 7 7 0 0 0 0 7 0 0 14 % T
% Val: 0 54 0 14 0 0 0 7 54 7 0 14 54 7 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 14 0 0 7 14 54 0 0 0 54 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _